Hello, I'm
Breveruos Sheheade
PhD in DNA Nanotechnology
Currently building AI research agents and privacy-first IoT systems
Researcher with hands-on engineering mindset. During my PhD, I designed self-assembling molecular machines - now I apply that same systematic approach to AI systems and automations. I build things that work.
About Me
I'm a researcher passionate about molecular machines and nanoscale engineering. I hold a PhD in DNA Nanotechnology from Ben-Gurion University, where I also completed a double degree in Chemical Engineering and Chemistry. Based in Kfar Yasif, Israel.
During my PhD at Prof. Eyal Nir's Lab, I developed autonomous propulsion mechanisms for rotary motors and created sophisticated DNA origami structures. My work combined experimental techniques with computational modeling to push the boundaries of nanoscale engineering.
Since completing my PhD, I've focused on independent R&D. I designed a multi-agent AI system for scientific literature retrieval - specialized agents collaborate to search, verify citations, and synthesize information from large documents (1000+ pages). I also build automation logic for privacy-first smart home systems using local compute.
I thrive in multidisciplinary settings and am eager to contribute to innovative projects across research, technology, and development. I bring a collaborative mindset focused on delivering impactful solutions.
Research Projects
Autonomous Propulsion Mechanism for Rotor
Introduced a novel concept for an autonomous artificial molecular motor - an unprecedented approach capturing key properties of biological motors. The mechanism leverages our DNA origami rotor framework with unique symmetry-breaking based on rotor geometry. A DNA bipedal walker, fueled by metastable DNA hairpins, strides along footholds positioned in the lower part of the rotor to drive rotation.
Key Achievements:
- Built mathematical model analyzing all interaction states
- Time-course simulations with multidimensional optimization
- Theoretical stepping rate: 1-3 min with <2% error per step
DNA Origami Structures for Lab Research
Designed and engineered multiple DNA origami structures. The primary structure is a ~90nm diameter rotary motor - a stator disc (housing a circular footholds track) connected via swivel (that can freely rotate) to the upper disc, which houses the bipedal walker and a 75x25nm gold nanorod for optical tracking via defocused light-scattering. The disc design process utilized self-developed tools, including a scaffold sequence redundancy analyzer, and multiple molecular dynamics methods to iteratively correct the inherent global twist. Also designed a 100x35nm capsule and 20x7nm rod.
Key Achievements:
- Flat disc structure confirmed via Cryo-TEM reconstruction
- Team achieved externally controlled walking: 72 steps (6 full turns) with 60% yield
- Capsule & rod structures folded and validated by other team members
DNA Origami Dimer & Hexamer Reactions
Led a project from senior year through PhD, achieving 99% yield for dimer reactions by correcting issues with excess annealing strand purification and bypassing unintended homodimerization via procedure optimization (vs typical 80-86%). Scaled to a ~1μm-long 6-mer track with 90% yield by developing 'NuCraft' - an algorithm generating sequences that prevent unintended hybridization beyond 6 bp. This track represents the foundation for micrometer-scale walker demonstrations.
AI-Assisted Research & Automation Tools
Built tools to address personal workflow challenges after PhD. Developed a multi-agent AI system with specialized subagents and verification loops - including PDF processing that produces traceable, source-backed conclusions, and deep web search for comprehensive research. Also designed automation logic for a local-compute smart home system using Home Assistant and Node-RED, handling edge cases like sensor failures and network drops.
Skills & Expertise
Scientific Expertise
AI & Systems
Computational & Visual Tools
Laboratory Techniques
Languages
Education
Direct Track Ph.D.
Ben-Gurion University of the Negev
Prof. Eyal Nir Lab, Chemistry Department
Development of autonomous propulsion mechanisms for rotary motors and DNA origami structures for artificial molecular machines.
Double B.Sc. Degree
Ben-Gurion University of the Negev
Nanotechnology-Specialized Program
Chemical Engineering (senior project: butyl alcohol production plant design) and Chemistry (specialized in physical chemistry, research on DNA origami dimerization).
Work Experience
Independent R&D
Personal Projects
Technical projects exploring AI tooling and IoT system design.
Teaching Assistant
Ben-Gurion University of the Negev
General Chemistry lab instructor for undergraduate students from various programs, including pharmacy, biology, and chemistry.
Publications
Peer-reviewed publications and manuscripts in preparation.
Self-Assembly of DNA Origami Heterodimers in High Yields and Analysis of the Involved Mechanisms
Sheheade, B., Liber, M., Popov, M., Berger, Y., Khara, D. C., Jopp, J., & Nir, E.
A High-Performance and Recoverable DNA Origami Rotary Motor
Shapira, H., Sheheade, B., Basak, S., Khara, C., & Nir, E.
Fabrication of a Micrometer Long DNA Hexamer Nanoribbon at High Yield and Purity
Sheheade, B., Popov, M., Basak, S., Shapira, H., Khara, D. C., & Nir, E.
Get In Touch
I'm currently open to new opportunities in research, technology, and development. Whether you have a question or just want to connect, I'll do my best to get back to you!
Designed & Built by Breveruos Sheheade | 2026
vibe coded ;)